Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 100886964
Gene Symbol: PTCSC3
PTCSC3 		0.340 Biomarker disease GENOMICS_ENGLAND Our data suggest that SNP rs944289 predisposes to PTC through a previously uncharacterized, long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor. 22586128 2012
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.900 SomaticCausalMutation disease ORPHANET Moreover, there was no overlap between PTC with RET/PTC, BRAF, or RAS mutations, which altogether were present in 66% of cases. 12670889 2003
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.900 SomaticCausalMutation disease ORPHANET Follicular variant of papillary thyroid carcinoma (FVPTC): histological features, BRAF V600E mutation, and lymph node status. 25702102 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.900 SomaticCausalMutation disease ORPHANET The frequencies of a positive BRAF(V600E) mutation by real-time PCR, positive BRAF V600E IHC, and high BRAF RNA ISH were 84%, 86%, and 70%, respectively, in PTC. 25468810 2015
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.900 SomaticCausalMutation disease ORPHANET Pax-8-PPAR-γ fusion protein in thyroid carcinoma. 25069464 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.900 SomaticCausalMutation disease ORPHANET BRAF mutation correlates with recurrent papillary thyroid carcinoma in Chinese patients. 25489262 2014
Entrez Id: 673
Gene Symbol: BRAF
BRAF 		0.900 SomaticCausalMutation disease ORPHANET Molecular genetics of papillary thyroid carcinoma: great expectations. 17891228 2007
Entrez Id: 7080
Gene Symbol: NKX2-1
NKX2-1 		0.700 SusceptibilityMutation disease ORPHANET Both FOXE1 and NKX2-1 were associated with the increased risk of sporadic Japanese PTC. 21730105 2011
Entrez Id: 5979
Gene Symbol: RET
RET 		0.600 FusionGene disease ORPHANET Our data reveal that both multiplex qPCR and FISH assays are equally applicable for detection of RET/PTC rearrangements. 25407564 2015
Entrez Id: 8030
Gene Symbol: CCDC6
CCDC6 		0.600 FusionGene disease ORPHANET Among 73 PTC patients with sufficient tissue available for FISH and multiplex qPCR, 10 cases were defined as RET/PTC positive by both assays, including eight CCDC6/RET and two NCOA4/RET fusions with relatively high RET mRNA. 25407564 2015
Entrez Id: 5979
Gene Symbol: RET
RET 		0.600 FusionGene disease ORPHANET Molecular genetics of papillary thyroid carcinoma: great expectations. 17891228 2007
Entrez Id: 2304
Gene Symbol: FOXE1
FOXE1 		0.500 SusceptibilityMutation disease ORPHANET Both FOXE1 and NKX2-1 were associated with the increased risk of sporadic Japanese PTC. 21730105 2011
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.400 FusionGene disease ORPHANET PAX8-PPARgamma1 fusion oncogene in human thyroid carcinoma [corrected]. 10958784 2000
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1 		0.400 FusionGene disease ORPHANET The NTRK1 gene in the q arm of chromosome 1 encodes one of the receptors for the nerve growth factor and is frequently activated as an oncogene in papillary thyroid carcinomas. 9172002 1997
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.400 SomaticCausalMutation disease ORPHANET RAS mutations in indeterminate thyroid nodules are predictive of the follicular variant of papillary thyroid carcinoma. 25109485 2015
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4 		0.400 FusionGene disease ORPHANET Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. 8290261 1994
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.400 SomaticCausalMutation disease ORPHANET Thyroid nodules with KRAS mutations are different from nodules with NRAS and HRAS mutations with regard to cytopathologic and histopathologic outcome characteristics. 25132659 2014
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1 		0.400 FusionGene disease ORPHANET Rearrangements of NTRK1 gene in papillary thyroid carcinoma. 19883730 2010
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1 		0.400 FusionGene disease ORPHANET The TFG sequence is fused to the 3' end of NTRK1, generating the TRK-T3 fusion transcript found in papillary thyroid carcinoma. 9169129 1997
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.400 SomaticCausalMutation disease ORPHANET Molecular genetics of papillary thyroid carcinoma: great expectations. 17891228 2007
Entrez Id: 729582
Gene Symbol: DIRC3
DIRC3 		0.400 SusceptibilityMutation disease ORPHANET Genome-wide association study on differentiated thyroid cancer. 23894154 2013
Entrez Id: 8031
Gene Symbol: NCOA4
NCOA4 		0.400 FusionGene disease ORPHANET Among 73 PTC patients with sufficient tissue available for FISH and multiplex qPCR, 10 cases were defined as RET/PTC positive by both assays, including eight CCDC6/RET and two NCOA4/RET fusions with relatively high RET mRNA. 25407564 2015
Entrez Id: 4893
Gene Symbol: NRAS
NRAS 		0.400 SomaticCausalMutation disease ORPHANET Preoperative RAS mutational analysis is of great value in predicting follicular variant of papillary thyroid carcinoma. 25648502 2015
Entrez Id: 7849
Gene Symbol: PAX8
PAX8 		0.400 FusionGene disease ORPHANET Low frequency of PAX8-PPARγ rearrangement in follicular thyroid carcinomas in Japanese patients. 25708358 2015
Entrez Id: 5468
Gene Symbol: PPARG
PPARG 		0.400 FusionGene disease ORPHANET Molecular genetics of papillary thyroid carcinoma: great expectations. 17891228 2007